Lobular carcinoma in situ (LCIS) is an area (or areas) of abnormal cell growth that increases a person’s risk of developing invasive breast. Lobular carcinoma in situ (LCIS) is an incidental microscopic finding with characteristic cellular morphology and multifocal tissue patterns. The condition is a. Lobular carcinoma in situ (LCIS) represents the next step up from atypical lobular hyperplasia (ALH) along the malignant spectrum of lobular breast carcinoma.

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If you have LCIS, you may want to consider taking a hormone medicine such as tamoxifen, raloxifene, or aromatase inhibitors to help reduce your risk of breast cancer.

Your individual risk of breast cancer is dependant upon many factors. Loading Stack – 0 images remaining.

Lobular carcinoma in situ | Radiology Reference Article |

Accessed April 25, National Breast Cancer Siru. It is important to establish a good support network and open and frequent communication with the primary physician. Estimated incidence of 2. What can you do to prepare for your appointment? What is more important is the aggressive nuclear features in the biopsy specimenand this can usually be accurately determined with a core biopsy only. There is no question that the presence of lobular carcinoma in situ confers a substantially higher risk for developing invasive breast cancer.


New author database being installed, click here for details. LCIS may be present in one or both breasts, but it usually is not visible on a mammogram.

Detailed analysis of 99 patients with average follow-up of 24 years. Talk to your doctor to better understand your personal risk of breast cancer. Clinical Significance and Immunoprofile.

Pathology Outlines – Lobular carcinoma in situ (LCIS)

Typically, physicians discover LCIS through a biopsy done for some other reason, such as an abnormal mammogram or suspicious breast lump. With LCIS, close follow-up is very important.

The malignant cells are small sutu regular, carcinoam distended acini berry-like bulges in the terminal lobule. Layer of LCIS cells beneath attenuated ductal epithelium. Wen HY, et al. Classic LCIS and invasive lobular lesions are low-grade ER and PR-positive cancers, referring to the positive expression of Estrogen and Progesterone receptors on the neoplastic cells determined via immunohistochemistry. American Society of Clinical Oncology. Small cell carcinoma Combined small cell carcinoma Verrucous carcinoma Squamous cell carcinoma Basal cell carcinoma Transitional cell carcinoma Inverted papilloma.

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Lobular Carcinoma in situ (LCIS)

Newer evidence is suggesting LCIS may be more of a pre-cancer than we thought. American society of clinical oncology.


Presence of lobular carcinoma in situ does not increase local recurrence in patients treated with breast-conserving therapy. In addition, in situ and invasive lesions exhibit loss of cellular adhesion, considered a characteristic histologic feature, due to the fact that e-cadherin expression is lost transmembrane protein involved in epithelial cell adhesion. What are the symptoms of lobular carcinoma in situ?

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If LCIS is detected in a breast biopsy, it doesn’t mean that you have cancer. World Journal of Clinical Oncology. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

Lobular Carcinoma in Situ (LCIS)

Marker for breast cancer risk”. Rather, your doctor might discover incidentally that you have LCIS.

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